separation of sedative – hypnotic drugs with mixed micellar liquid chromatography
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abstract
separation of ten sedative- hypnotic drugs was performed by rp-hplc using mixed micellar mobile phase. effect of temperature, type and amount of organic modifier in mobile phase on efficiency (n) and asymmetry factor (b/a) showed that, the appropriate conditions for a good separation were 35°c and 7% (v/v) butanol in mobile phase. variations of selectivity factor versus butanol concentration, mixture of sds/ brij- 35 concentrations and ph of mobile phase showed that the appropriate conditions were 7%(v/v), 15 mm sds +1.0mm brij-35 and ph=3 in mobile phase respectively.
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Journal title:
iranian journal of chemistry and chemical engineering (ijcce)Publisher: iranian institute of research and development in chemical industries (irdci)-acecr
ISSN 1021-9986
volume 24
issue 2 2005
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